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Share 13k shares Intricate details: Sandra painted the jeans on with extreme detail making sure to include pockets and seams Faux-jeans: She used different coloured blues to create a distressed look for the denim With her pants painted on, the model stepped out on to the busy street where she crossed roads, shopped, looked at artwork and stepped on to a packed train. Despite not wearing any pants, most passers-by appeared not to notice. It was not until she stopped to buy a train ticket that a man did a double-take, walking slowly past the woman as he looked at her 'jeans'. The model walked around the streets of Hong Kong undetected Double take:
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One promising candidate for treatment is the drug rapamycin, which has been shown to extend lifespan in multiple animal models, and which was previously shown to ameliorate mitochondrial disease in a knock-out mouse model lacking a nuclear-encoded gene specifying an OxPhos structural subunit Ndufs4. In that model, relatively high-dose intraperitoneal rapamycin extended lifespan and improved markers of neurological disease, via an unknown mechanism. Here, we administered low-dose oral rapamycin to a knock-in KI mouse model of authentic mtDNA disease, specifically, progressive mtDNA depletion syndrome, resulting from a mutation in the mitochondrial nucleotide salvage enzyme thymidine kinase 2 TK2. We found no evidence that rapamycin increased survival by acting through canonical pathways, including mitochondrial autophagy. However, transcriptomics and metabolomics analyses uncovered systemic metabolic changes pointing to a potential 'rapamycin metabolic signature.
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Sandra Bakker's model walks around Hong Kong NAKED from the waist down

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