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Lancaster Road, Dallas, TX Abstract Neurophysiologic processes underlie the uncontrolled, compulsive behaviors defining the addicted state. This review of preclinical and clinical primarily neuroimaging studies will describe how the delineation between pleasure, reward, and addiction has evolved as our understanding of the biologic mechanisms underlying these processes has progressed. Although the mesolimbic dopaminergic efflux associated with drug reward was previously considered the biologic equivalent of pleasure, dopaminergic activation occurs in the presence of unexpected and novel stimuli either pleasurable or aversive and appears to determine the motivational state of wanting or expectation.
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